Build Your Bioprocess with Better Control
Your Fermentation Worked in the Lab. Will It Scale? fermenter systems A fermentation process can perform perfectly in a laboratory and still behave differently when moved to a larger system. That is one of the most important challenges in bioprocess development and it is easy to underestimate. At laboratory scale, everything is easier to observe and control. The vessel is smaller, mixing happens quickly, temperature changes can be managed efficiently, and oxygen can reach the culture relatively easily. Then the volume increases, and suddenly the same process has to work under very different physical conditions. The biology has not changed. The environment around it has. That is why fermentation scale-up is not simply a matter of increasing the working volume. It is about maintaining the conditions that allowed the original process to succeed. When Laboratory Fermentation Stops Scaling A successful laboratory batch can create the impression that the process is already so...